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Aligos Therapeutics
Aligos Therapeutics (ALGS) investor relations material
Aligos Therapeutics Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary17 Nov, 2025
Portfolio overview and pipeline updates
Lead program pevifoscorvir (pevi) targets hepatitis B, showing strong phase II progress and unique dual mechanisms of action.
Additional assets include ALG-009 (beta thyroid agonist for MASH), a pan-coronavirus protease inhibitor in phase II, and preclinical antisense oligonucleotides for HBV and HDV.
Pevi is the first capsid assembly modulator in the clinic to demonstrate effects on cccDNA, a key viral reservoir.
Phase II global study of pevi is ongoing, with interim analysis expected early next year and top-line data in 2027.
ALG-009 shows superior potency and pharmacokinetics compared to competitors, with phase II-B readiness and potential for accelerated development.
Clinical results and competitive positioning
Pevi monotherapy achieves rapid and sustained HBV DNA suppression, outperforming standard nucleoside analogs in both E positive and E negative patients.
No drug resistance observed with pevi, even against variants resistant to other capsid assembly modulators, enabling monotherapy and regulatory alignment.
Pevi reduces HBV surface and E antigens, indicating cccDNA suppression; antigen reductions are maintained after therapy cessation.
Safety profile is favorable, with no discontinuations due to adverse events and only transient ALT elevations.
Pevi is positioned as a future standard of care for chronic HBV suppression and as a combination partner for functional cure regimens.
Market need and future milestones
Chronic HBV remains a major global health issue, with current therapies leaving most patients at risk for liver disease and cancer.
Pevi addresses the unmet need for broader and deeper viral suppression, especially for patients ineligible for functional cure therapies.
Upcoming milestones include interim phase II analysis (early next year) and primary endpoint readout in 2027.
ALG-009 demonstrated nearly double the fat reduction of a leading competitor in MASH and may enhance weight loss when combined with incretins.
Full data on ALG-009’s metabolic effects to be presented at an upcoming Hep-DART meeting.
Pevi's resistance profile and implications
Pevi's market positioning for HBV patients
ALG-009's differentiation in MASH and obesity
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Latest summaries
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- 5 FebGL
Earnings and premium growth were strong, with higher 2026 guidance and ongoing share buybacks. - 5 FebABX
Record 2025 results, strong cash flow, and North America gold IPO planned for late 2026. - 5 FebWEX
Q4 2025 revenue and EPS grew strongly, with 2026 guidance projecting continued momentum. - 5 FebCLFD
FY25 sales rose 20% to $150.1M, with improved margins and strong growth outlook for FY26. - 5 FebMAA
Q4 and 2025 results met expectations; 2026 outlook sees modest growth and easing supply. - 5 FebDG
Record free cash flow and broad-based earnings growth drive strong 2025 results and positive 2026 outlook. - 5 FebMOD
Q3 FY26 sales up 31%, strong data center growth, pension charge led to net loss, major spin-off announced. - 5 FebAPOLLOTYRE
Record revenue, profit growth, major expansion, and improved financial metrics in Q3 FY26. - 5 FebCMI
Record 2025 results, $458M Accelera charges, and 2026 growth led by data center power. - 5 FebHP
EBITDA $230M, $1.02B revenue, net loss $97M, $260M debt repaid, strong tech rollout.
Next Aligos Therapeutics earnings date
Q4 20259 Mar, 2026
Aligos Therapeutics
Next Aligos Therapeutics earnings date
Q4 20259 Mar, 2026
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Frequently asked questions
Aligos Therapeutics Inc. is a clinical-stage biopharmaceutical company engaged in the development of novel therapeutics to address unmet medical needs in viral and liver diseases. The company's development pipeline includes drug candidates for the treatment of conditions such as non-alcoholic steatohepatitis (NASH), chronic hepatitis B (CHB), and coronavirus. Aligos Therapeutics utilizes a combination of small molecule and oligonucleotide platforms to create pharmacologically optimized drug candidates aimed at improving treatment outcomes in these diseases. The company is headquartered in South San Francisco, California, and its shares are listed on the Nasdaq.
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