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Apellis Pharmaceuticals
Apellis Pharmaceuticals (APLS) investor relations material
Apellis Pharmaceuticals 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.44th Annual J.P. Morgan Healthcare Conference summary12 Jan, 2026
Strategic focus and growth outlook
Emphasis on complement pathway therapies, with SYFOVRE and EMPAVELI as key growth drivers for both near and long term.
2025 described as a foundational year, building revenue streams and pipeline for future expansion.
2026 priorities include maximizing SYFOVRE in geographic atrophy, expanding EMPAVELI in rare nephrology, and advancing next-generation therapies.
Company remains self-funded, prioritizing commercial execution, pipeline development, and capital deployment to drive revenue and profitability.
Global expansion strategies under consideration, including potential European market re-entry.
SYFOVRE: Market leadership and innovation
Maintains ~60% market share in geographic atrophy, with $587M in 2025 U.S. net product revenue and stable new patient share at 50-55%.
Five-year GALE data demonstrated durable efficacy and safety, supporting long-term use.
Prefilled syringe program and regulatory submission planned (2024–1H 2026) to enhance adoption and streamline retina practice workflow.
AI-driven functional OCT imaging and augmented reality tools enhance demonstration of patient benefit and early GA identification.
Market growth supported by improved practice flow and anticipated expansion into early-stage patient segments.
EMPAVELI: Rare disease launch and pipeline expansion
EMPAVELI approved for C3G and IC-MPGN, with >5% market penetration after first full quarter and strong early launch.
Generated $102M in FY 2025 U.S. net product revenue and demonstrated robust efficacy and safety across indications.
Launch success attributed to strong efficacy, safety profile, positive payer reception, and start form performance outpacing other rare nephrology launches.
Ongoing pivotal trials in FSGS and DGF target significant unmet needs in rare kidney diseases.
Pediatric and transplant populations show higher urgency and uptake.
SYFOVRE EMA approval strategy?
EMPAVELI 2026 growth drivers and differentiation
APL9099 tech advantages vs. gene editing peers
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Next Apellis Pharmaceuticals earnings date
Q4 202527 Feb, 2026
Apellis Pharmaceuticals
Next Apellis Pharmaceuticals earnings date
Q4 202527 Feb, 2026
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Frequently asked questions
Apellis Pharmaceuticals Inc. is a biopharmaceutical company focused on developing therapies for autoimmune and rare diseases. The company’s research is centered around complement inhibition, targeting the C3 protein in the complement system, which plays a key role in immune response. Apellis’ lead products and drug candidates aim to treat conditions such as geographic atrophy (a form of age-related macular degeneration) and paroxysmal nocturnal hemoglobinuria (PNH), among other serious diseases. The company is headquartered in Waltham, Massachusetts, and its shares are listed on the NASDAQ.
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