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Arrowhead Pharmaceuticals Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary4 Dec, 2025
Key accomplishments and product launches
Launched first drug, Redemplo (plozasiran), for FCS after nearly two decades of development.
Redemplo approved to reduce triglycerides in both genetic and clinical FCS, expanding commercial reach.
Ongoing Phase 3 studies (SHASTA-3, SHASTA-4, SHASTA-5, MUIR) to support further indications and safety data.
sNDA filing for SHTG planned by end of 2026, with potential launch in 2027.
Competitive landscape and market opportunity
Market for high triglyceride therapies is underserved, with significant unmet need.
Collaboration with Ionis on disease education and market growth, rather than direct competition.
Both companies aim to expand the market for triglyceride-lowering drugs.
Clinical trial design and upcoming data
SHASTA-3 and SHASTA-4 are placebo-controlled, enrolling severe SHTG patients, with primary endpoint of TG lowering at 12 months.
37% of patients had TGs over 880 mg/dL, and 20% had history of pancreatitis.
Liver fat data from SHASTA-3/4 expected in Q3 next year; no prior signal seen in earlier studies.
Redemplo's SHTG market opportunity and launch timeline
PCSK9 ApoC3 dimer key development risk
ALK7/Inhibin E pathway inhibition markers
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Next Arrowhead Pharmaceuticals earnings date
Q1 20269 Feb, 2026
Next Arrowhead Pharmaceuticals earnings date
Q1 20269 Feb, 2026
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Arrowhead Pharmaceuticals Inc develops therapies that leverage RNA interference (RNAi) to treat genetic diseases. Its pipeline targets conditions in areas such as liver disease, cardiovascular disease, and oncology. The company is headquartered in Pasadena, California, and its shares are listed on the NASDAQ.
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