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BioAge Labs Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary4 Dec, 2025
Key clinical data and program updates
Presented first clinical results for a brain-penetrant NLRP3 inhibitor, showing target coverage in brain and periphery at 60 mg and complete IL-1 beta shutoff at 120 mg, with good safety and tolerability.
Initial focus is on CRP reduction in obese individuals with elevated cardiovascular risk, with a proof-of-concept study planned for next year and a three-month monotherapy trial to follow.
Two additional MAD cohorts in obese patients with high CRP will read out in the first half of next year, aiming to inform broader indication strategy.
The three-month study will start mid-next year, with a comprehensive biomarker analysis expected in the second half of the year.
No dose-limiting toxicity observed up to 120 mg; all adverse events have been mild to moderate.
Strategic priorities and differentiation
Prioritizing indications where the company can advance programs independently, leveraging unique brain and retina penetration properties.
Differentiation includes a novel NLRP3 binding site, best-in-class potency, and ability to inhibit CAPS mutations not addressed by other inhibitors.
Only three brain-penetrant NLRP3 programs are in the clinic; the asset offers once-daily dosing compared to competitors.
Additional indications, including neurodegenerative and ocular diseases, are under consideration, with plans to announce next steps after initial CRP data.
Portfolio includes a follow-on brain-penetrant compound and potent peripherally restricted inhibitors, with ongoing investment in pipeline expansion.
Financial and operational outlook
Cash balance of approximately $300 million provides a runway of about three years, covering planned studies and early-stage pipeline development.
Discovery platform leverages DNA-encoded library screening and structural biology collaborations, enabling rapid portfolio expansion.
Strategy includes advancing some indications independently through phase III while seeking partnerships for larger indications like ASCVD and Alzheimer's.
Indication selection will be guided by early clinical data and the ability to maximize value and operational feasibility.
Ongoing evaluation of a broad range of potential indications, with updates expected as data matures.
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Next BioAge Labs earnings date
Q4 202520 Mar, 2026
Next BioAge Labs earnings date
Q4 202520 Mar, 2026
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Frequently asked questions
BioAge Labs Inc. is a biotechnology company focused on developing therapies to extend healthy human lifespan by targeting the biological pathways of aging. The company utilizes a proprietary platform that combines machine learning, genomics, and biomarker analysis to identify and develop drug candidates aimed at treating age-related diseases, such as those affecting muscle health, immune function, and metabolism. BioAge Labs conducts research to address the underlying biological factors of aging with the goal of improving health outcomes in later life. The company is headquartered in Richmond, California, and its shares are listed on the Nasdaq.
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