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Company Research20 Mar 2024
Companies That Had Their IPO in 1991: Recovery From a Recession
An overview of the markets and the IPO landscape as the economy recovered from the early 90s recession.
Biogen (BIIB) investor relations material
Biogen Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary3 Dec, 2025
Immunology pipeline overview
Focus on advanced development of immunology assets, with major data readouts expected over the next few years.
Felzartamab, a CD38-directed therapy, targets antibody-producing plasma cells implicated in multiple autoimmune diseases.
CD38 targeting offers a more selective approach, sparing earlier B cell populations and addressing diseases where current therapies are ineffective.
Felzartamab clinical development and data
Late antibody-mediated rejection (AMR) in renal transplant is the lead indication, affecting about 11,000 patients and representing the top cause of late graft loss.
Phase 2 trial showed unprecedented reversal of microvascular inflammation in AMR, with 80% achieving inactive disease at six months; some reversal noted by 12 months off therapy.
Phase 3 design includes crossover from placebo to active treatment at six months, with maintenance therapy for initial felzartamab group; top-line 12-month data expected in 2027.
Primary endpoint is histologic reversal of AMR, with supportive biomarker and kidney function data.
Expansion into other renal and autoimmune indications
IgA nephropathy program aims to offer durable disease control off treatment, differentiating from competitors that require ongoing dosing.
Felzartamab’s mechanism directly depletes disease-driving plasma cells, with phase 2 data showing sustained reduction in proteinuria and IgA for up to two years post-treatment.
Enrollment in pivotal IgA nephropathy study benefits from increased disease awareness and limited availability of other therapies.
In primary membranous nephropathy (PMN), felzartamab targets high-risk and CD20-refractory patients, addressing up to 50% who do not respond or relapse after CD20 therapy.
Felzartamab's durable IgAN control vs. competitors
Phase III AMR histology reversal data significance
Lupus program endpoint strategy rationale
Partial view of Summaries dataset, powered by Quartr API
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Next Biogen earnings date
Q4 202512 Feb, 2026
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Frequently asked questions
Developing Breakthrough Medications
Biogen is a multinational biotechnology company operating in the field of discovery, development, and sale of various. The company was established in 1978 and is based in Cambridge, Massachusetts. Over the years, Biogen has emerged as a key player in the biotech sector, specifically in neurology, with several therapies targeting multiple sclerosis (MS) and spinal muscular atrophy (SMA). Beyond neurology, their portfolio spans therapies for conditions such as hemophilia and other rare disorders.
Decades of Experience
Founded in 1978, Biogen stands as one of the world's oldest independent biotechnology companies. Its roots trace back to a group of scientists who recognized the potential of biotechnology to produce breakthrough medicines. In addition to its offerings of medications currently on the market, the company has consistently invested in research and development, leading to numerous innovations in the biotechnology sector. Biogen has consistently been able to develop marketable medications that make a positive impact on patient health. The company has expanded through a combination of organic growth as well as through collaborations and acquisitions over the years.
The Portfolio
Biogen has a vast therapeutic portfolio of various medications. The company has developed a range of therapies over the years, with several being first-of-their-kind or best-in-class. A standout is their focus on neurology, particularly in multiple sclerosis. Products like TECFIDERA and AVONEX have been game-changers in the MS treatment landscape. Additionally, SPINRAZA, designed for spinal muscular atrophy, is another prime example of Biogen's novel treatments addressing severe medical conditions. The company is also constantly working on developing new drugs
A Global Company
The company has a significant global presence, spanning countries across multiple continents. Their expansive distribution network ensures that their therapies are accessible to patients around the world. This is nothing unique for this type of company and the world's largest biotechnology companies and medication producers such as Pfizer, Eli Lilly, and Amgen, to mention a few, all operate on a global scale.
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