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C4 Therapeutics
C4 Therapeutics (CCCC) investor relations material
C4 Therapeutics Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary3 Dec, 2025
Clinical program updates
Two active clinical programs: cemsidomide (IKZF1/3 degrader) and CFT8919 (EGFR L858R degrader) are progressing, with cemsidomide moving to the next phase early next year and CFT8919 in a phase one study in China.
Cemsidomide phase one showed a 36% ORR overall, with 40% and 53% ORR at the two highest doses; two complete responses observed at 100 mcg.
Safety profile for cemsidomide is favorable, with no discontinuations due to safety and only 6% dose reductions; most adverse events were not drug-related.
100% of patients were triple-class exposed, and 75% had prior CAR T or T-cell engager therapy; response rates were consistent across these subgroups.
Cemsidomide's efficacy and safety profile compare favorably to mezigdomide, with a more refractory patient population and fewer neutropenic complications.
Regulatory and development plans
No further phase one updates planned for cemsidomide; focus is on advancing to phase two, with an FDA meeting on dose alignment scheduled for later this month.
A prior Type C meeting with the FDA provided feedback shaping current development plans.
The upcoming global 4L+ study will enroll triple-class refractory patients, with a target ORR of around 40% to demonstrate significant improvement over the 20% background rate.
Confidence in single-arm study approval is based on precedent, but regulatory risk remains due to evolving standards and agency personnel.
Commercial and financial outlook
Pricing for cemsidomide is expected to be competitive with current market analogs, but specifics are not disclosed.
Duration of response in late-line settings is currently 9.3 months, exceeding the typical six-month benchmark.
Cash runway extends through the end of 2028, not including up to $40 million in potential milestone payments from partners over 2026–2027.
Key data readouts from the phase two MOMENTUM study are expected by late 2027 (investigator assessment) and later in 2028 (central assessment).
Cemsidomide's competitive edge vs. Mezigdomide?
Confidence in single-arm cemsidomide approval?
CFT8919 development plan post-Q1 2026 decision?
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Next C4 Therapeutics earnings date
Guggenheim Securities Emerging Outlook: Biotech Summit 202611 Feb, 2026
C4 Therapeutics
Next C4 Therapeutics earnings date
Guggenheim Securities Emerging Outlook: Biotech Summit 202611 Feb, 2026
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Frequently asked questions
C4 Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on targeted protein degradation to develop novel therapies. The company is active in the development of small-molecule medicines designed to selectively target and degrade disease-causing proteins. C4 Therapeutics is leveraging its proprietary technology platforms to advance a pipeline of drug candidates aimed at treating a range of diseases, such as cancer, neurodegenerative conditions, infectious diseases, and autoimmune disorders. The company is headquartered in Watertown, Massachusetts, and its shares are listed on the Nasdaq under the symbol CCCC.
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