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Cabaletta Bio (CABA) investor relations material
Cabaletta Bio Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Advanced two innovations: rese-cel with no preconditioning and automated manufacturing using Cellares Cell Shuttle, with clinical data expected in 1H26 and durability data throughout 2026.
Registrational cohort for myositis enrolling, targeting a 2027 BLA submission; pivotal trial designs for SLE and LN announced, with SSc design update expected in 1H26.
RESET clinical program spans multiple autoimmune diseases in rheumatology, neurology, and dermatology.
Financial highlights
Research and development expenses rose to $36.2M for Q4 2025 and $142.7M for FY 2025, up from $25.5M and $97.2M in 2024.
General and administrative expenses were $6.4M for Q4 2025 and $29.6M for FY 2025, compared to $8.3M and $27.9M in 2024.
Net loss for Q4 2025 was $41.9M and $167.9M for FY 2025, compared to $32.6M and $115.9M in 2024.
Cash, cash equivalents, and short-term investments totaled $133.6M as of December 31, 2025, with an additional $30M raised in Q1 2026.
Cash position expected to fund operations into Q4 2026.
Outlook and guidance
Initial RESET-SLE data (no preconditioning) expected in 1H26, with durability data from RESET-SLE and RESET-PV throughout 2026.
Complete Phase 1/2 data from RESET-SSc, RESET-SLE, and RESET-MG trials to be presented in 1H26.
Update on registrational designs for RESET-SSC in 1H26 and RESET-MG in mid-2026.
BLA submission for rese-cel in myositis planned for 2027.
- Rese-cel delivers transformative, outpatient-ready CAR T therapy for autoimmune diseases.CABA
Corporate presentation23 Mar 2026 - Automated CAR T manufacturing and no preconditioning may revolutionize autoimmune therapy.CABA
TD Cowen 46th Annual Health Care Conference3 Mar 2026 - Automated manufacturing and outpatient CAR-T therapy drive a scalable, high-margin business model.CABA
Guggenheim Securities Emerging Outlook: Biotech Summit 202612 Feb 2026 - Pivotal CD19-CAR T trials show strong efficacy, safety, and outpatient potential in autoimmunity.CABA
Corporate presentation12 Feb 2026 - CABA-201 shows strong safety, immune reset, and early efficacy in autoimmune disease trials.CABA
Study Update3 Feb 2026 - Broad autoimmune cell therapy trials advance with strong enrollment and key data updates expected soon.CABA
2024 Wells Fargo Healthcare Conference22 Jan 2026 - CABA-201 advances in autoimmune CAR-T with rapid enrollment, robust data, and manufacturing innovation.CABA
Morgan Stanley 22nd Annual Global Healthcare Conference22 Jan 2026 - Accelerating enrollment and innovative trial design position the program for transformative impact.CABA
H.C. Wainwright 26th Annual Global Investment Conference 202421 Jan 2026 - Accelerated enrollment and site expansion position CABA-201 as a leader in autoimmune CAR T trials.CABA
2024 Cantor Fitzgerald Global Healthcare Conference20 Jan 2026
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