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Camp4 Therapeutics (CAMP) investor relations material
Camp4 Therapeutics Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Platform overview and scientific approach
Focuses on regulatory RNAs (regRNAs) that control gene expression via promoters and enhancers.
Drugging specific regRNAs with antisense oligonucleotides can upregulate protein-coding genes, ideal for haploinsufficiency disorders.
Platform enables efficient mapping and analytical targeting of gene regulation in any cell type.
Antisense oligonucleotides allow rapid development of candidates to restore missing proteins.
Lead program: SYNGAP1-related disorders
SYNGAP1 is critical for synaptic function; deficiency leads to seizures, learning disabilities, and motor issues.
Most patients have haploinsufficient mutations, producing only 50% of normal protein levels.
Estimated over 10,000 patients in the U.S. and a similar number globally.
Diagnosis now more streamlined due to genetic panels and patient advocacy efforts.
Preclinical and clinical progress
Demonstrated full recovery of SYNGAP protein in patient-derived cells and reversal of cognitive symptoms in humanized mouse models.
Achieved dose-responsive, significant increases in SYNGAP in critical brain regions in primates.
GLP-tox studies for CMP-002 began in Q3; clinical entry expected in the second half of next year.
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