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CervoMed Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary7 Nov, 2025
Executive summary
Clinical-stage biotech focused on age-related brain disorders, with lead candidate neflamapimod targeting neuroinflammation and neurodegeneration in DLB and other indications.
Completed Phase 2b RewinD-LB Trial in DLB, showing statistically significant and durable clinical and biomarker improvements, and aligned with FDA for a planned Phase 3 trial.
Preparing for a global pivotal Phase 3 trial in DLB in the second half of 2026, with additional Phase 2a data in FTD and stroke recovery expected in 2026.
Appointed new Chief Commercial and Business Officer and added a new Board member.
Financial highlights
Cash, cash equivalents, and marketable securities totaled $27.3 million as of September 30, 2025, down from $38.9 million at December 31, 2024.
Net loss was $18.9 million for the nine months ended September 30, 2025, compared to $9.6 million for the same period in 2024.
Grant revenue recognized was $4.0 million for the nine months ended September 30, 2025, down from $7.6 million in 2024.
R&D expenses increased 37% year-over-year to $16.0 million; general and administrative expenses rose 16% to $8.0 million.
Net loss for Q3 2025 was $7.7 million, compared to $4.8 million in Q3 2024.
Outlook and guidance
Cash on hand is expected to fund operations into Q3 2026 based on current plans, but substantial doubt exists about ability to continue as a going concern without additional funding.
Plans to initiate a global Phase 3 trial in DLB in the second half of 2026, pending additional funding.
Will continue to seek additional financing through equity, debt, or strategic arrangements.
Quantify impact of NIA grant's remaining 2% uncertainty
Rationale for Phase 3 DLB patient exclusion criteria
Update on expense account control weakness remediation
Explain the Phase 3 DLB patient enrichment strategy
How will CervoMed fund Phase 3 DLB trial?
What was the December 2024 drug product issue?
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Frequently asked questions
CervoMed Inc. is a biotechnology company specializing in the development and commercialization of treatments for age-related neurologic disorders. The company’s key focus is on addressing synaptic dysfunction, a critical factor in neurodegenerative diseases. Its lead product candidate, neflamapimod, is an orally administered small molecule designed to treat conditions such as dementia with Lewy bodies, Alzheimer's disease, and frontotemporal dementia by reversing synaptic dysfunction. CervoMed also has additional programs targeting central nervous system disorders in earlier stages of development. The company is headquartered in Boston, Massachusetts, and its shares are listed on the NASDAQ.
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