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Climb Bio (CLYM) investor relations material
Climb Bio Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary2 Dec, 2025
Key milestones and upcoming data
2026 will be pivotal with multiple data readouts for two clinical-stage monoclonal antibodies targeting rare autoimmune diseases.
Budoprutug (CD19 mAb) will have subQ formulation data in healthy volunteers in H1 2026, and ITP/SLE data in H2 2026.
CLYM116 (anti-APRIL) for IgA nephropathy will have healthy volunteer data mid-2026.
Additional milestones and indication strategy updates are expected in the coming months.
Dose-ranging studies will inform phase III dose selection across all three indications.
Program differentiation and strategy
Budoprutug is one of only two CD19 mAbs in clinical development, with high affinity and subQ formulation for broader patient access.
Indications chosen include PMN (lead), ITP, and SLE, all with high unmet needs and commercial potential.
PMN has no approved therapies and represents a significant opportunity; regulatory path is clear with a single 150-patient registrational study.
ITP and SLE development will depend on achieving meaningful clinical benefit and safety, with high bars for further advancement.
Dose optimization is tailored to each indication, with subQ formulation planned for phase III if advanced.
Clinical development and data expectations
PMN efficacy will be measured by rapid and high rates of proteinuria reduction and renal response.
ITP success will be defined by durable remission and increased platelet counts, reducing need for chronic therapy.
SLE program focuses on safety, immune reset, and identifying responsive subtypes, especially renal.
Dose selection is informed by deep B-cell depletion and biomarker analysis, not just peripheral B-cell suppression.
SubQ Budo PK/PD data will be available in H1 2026, guiding phase III planning.
Budo: ITP/SLE data bar vs PMN
How will 116's sweeper mechanism be demonstrated?
What drives Budo's dose selection strategy?
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Q4 202527 Mar, 2026
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Eliem Therapeutics, Inc. is a biotechnology company focused on developing therapies for neuronal excitability disorders, which are associated with conditions like chronic pain, epilepsy, depression, and anxiety. The company’s approach involves advancing clinical-stage compounds that target neurological diseases, aiming to address significant unmet medical needs. Eliem Therapeutics is headquartered in Wilmington, Delaware, and its shares are listed on the NASDAQ.
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