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Compass Therapeutics (CMPX) investor relations material
Compass Therapeutics Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary4 Dec, 2025
Strategic pipeline updates and clinical milestones
Four oncology drugs in development, with three in the clinic and a fourth entering trials early next year.
Lead program Tevecimig (DLL4 VEGF-A bispecific) to report PFS and OS secondary endpoints in Q1 2026.
PD-1, PD-L1 bispecific antibody showed three responses in first 15 patients, including refractory cases; cohort expansions in TNBC and NSCLC planned.
Novel PD-1 VEGF-A bispecific entering clinic early next year, with four phase I indications planned.
CD137 agonist antibody to begin biomarker-driven basket study in first half of next year.
Clinical data highlights and efficacy signals
Tevecimig tripled response rate over control in BTC, with lower progressive disease incidence (16% vs 42% at week 8).
Fewer deaths than projected in randomized BTC study, suggesting improved OS and a potential tail on the Kaplan-Meier curve.
Median PFS in phase II BTC study was 9.4 months; conservative lower bound at 5.4 months, exceeding current second-line chemotherapy.
PD-1, PD-L1 bispecific showed responses in heavily pretreated, post-checkpoint patients, including near CR in NSCLC and durable response in TNBC.
No dose-limiting toxicities observed up to 10 mg/kg in phase I PD-1, PD-L1 bispecific study.
Market opportunity and commercial strategy
Second-line BTC market estimated at 15,000 US patients annually, with potential for six months on drug and multi-billion-dollar opportunity.
Frontline BTC expansion ongoing at MD Anderson, with potential to increase patient pool by 50%.
Additional expansion opportunities in DLL4-expressing tumors: hepatocellular, gastric, ovarian, renal cell, and colorectal cancers.
Commercial-ready manufacturing process established for Tevecimig; pre-launch and prescriber awareness initiatives underway.
Academic medical centers involved in trials position the company for strong prescriber engagement ahead of a potential 2027 launch.
Beyond BTC, which tumor types offer largest Tovecimig opp
8371's post-checkpoint responses: what's next?
Does PD-1xVEGF also show PD-1 cleavage?
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Next Compass Therapeutics earnings date
44th Annual J.P. Morgan Healthcare Conference14 Jan, 2026
Next Compass Therapeutics earnings date
44th Annual J.P. Morgan Healthcare Conference14 Jan, 2026
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Frequently asked questions
Compass Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing antibody-based therapeutics primarily targeting oncology. The company’s research centers on the interaction between angiogenesis, the immune system, and tumor growth. Its pipeline includes novel therapeutic candidates designed to modulate key biological pathways to elicit an effective anti-tumor response. This includes strategies to influence the tumor microvasculature, activate immune cells, and overcome immunosuppressive mechanisms employed by tumors. The company is headquartered in Boston, Massachusetts, and its shares are listed on the NASDAQ.
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