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Coya Therapeutics (COYA) investor relations material
Coya Therapeutics Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Key accomplishments and milestones in 2025
Lead asset advanced into a potentially registration-enabling clinical trial.
Interim data from an investigator-initiated trial in frontotemporal dementia showed promising results.
Preclinical data demonstrated synergistic potential of GLP-1s with proprietary low-dose interleukin-2.
Notable publications and external validation, including a Nobel Prize awarded to a scientific advisory board member.
Scientific platform and strategy
Focused on neurodegenerative diseases by restoring Treg numbers and function to reduce inflammation.
Utilizes a combination biologic approach with low-dose interleukin-2 and CTLA-4 to sustain Treg function.
Consistent results across small trials in ALS, FTD, and Alzheimer's, showing disease progression can be slowed.
Clinical development and trial design
ALS phase II trial is a randomized, double-blind, placebo-controlled study with 120 patients and a six-month primary endpoint (ALSFRS).
Secondary endpoints include neurofilament light and oxidative stress biomarkers, with patient stratification by disease severity.
After six months, placebo patients are re-randomized to treatment for an additional year to gather further data.
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