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Edwards Lifesciences (EW) investor relations material

Edwards Lifesciences Investor Day 2025 summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Investor Day 2025 summary4 Dec, 2025

Strategic vision and innovation

  • Focus on large, complex unmet patient needs with a strategy to lead and define new therapeutic categories, including TAVR, tricuspid, mitral, pulmonic, and aortic regurgitation therapies, and a patient-centered approach to structural heart disease.

  • Expanded reach through global presence in 100+ countries, 16,000 employees, and a resilient supply chain, with a strong culture and impact on the healthcare ecosystem.

  • Heavy R&D investment: over $1B annually, $1.6B external, with above 20% R&D return, 10,000+ patents, 1,000+ publications, and $40B+ in population-wide health gain from TAVR.

  • Diversified growth drivers now include TAVR, mitral, tricuspid, surgical, and emerging opportunities in structural heart failure and aortic regurgitation.

  • Commitment to continuous innovation and long-term value creation for patients, physicians, health systems, and shareholders.

Financial guidance and growth outlook

  • 2025 guidance: 8%-10% total sales growth, TAVR growth 5%-7%, TMTT sales growth 50%-60% to $500M+, and EPS of $2.40-$2.50.

  • 2026 guidance: 8%-10% sales growth, $6.4B-$6.8B sales, adjusted EPS $2.80-$2.95, operating margin expansion of ~100bps, and TAVR $4.6-$4.9B (6%-8% growth), TMTT $740-$780M (35%-45% growth), Surgical $1.05-$1.13B (mid-single digit growth).

  • Long-term: Targeting ~10% average annual sales growth, double-digit EPS growth, TMTT to reach $2B by 2030, and mid- to high-single-digit TAVR growth.

  • Capital deployment focused on R&D, strategic acquisitions, manufacturing, and share repurchases, maintaining >20% ROIC and a strong, flexible balance sheet.

  • Continued investment in R&D and adjacent therapies, with a focus on clinician and patient education and improving R&D ratio as a percent of sales.

Product and clinical pipeline highlights

  • TAVR: SAPIEN platform remains the global benchmark, with new indications, SAPIEN 3 Ultra RESILIA adoption, SAPIEN X4, and pivotal PROGRESS trial data expected at TCT 2026.

  • TMTT: Launches of EVOQUE, PASCAL, and SAPIEN M3 to expand patient pool; FDA approval of SAPIEN M3 expected early 2026; robust evidence from TRISCEND II and CLASP II trials.

  • Surgical: INSPIRIS, KONECT, MITRIS with RESILIA tissue technology showing strong adoption; U.S. launch of TRIFORMIS, the first surgical tricuspid valve, expected H2 2026.

  • Heart failure: Cordella system and new IHFM business targeting 1.2M high-risk patients, with PRO2 trial to support guideline updates and V-LAP in development.

  • AR: Acquisitions of J-Valve and JenaValve to address aortic regurgitation, with clinical trials underway and JenaValve acquisition pending.

Asymptomatic trial: disease vs device trial implications?
SAPIEN valve dock: key US market learnings?
Strategy to overcome skepticism for new therapies?
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Frequently asked questions

Edwards Lifesciences Corporation is an innovative medical-device company, providing products in structural heart disease, and critical care and surgical monitoring that can improve healthcare worldwide. Our comprehensive portfolio includes devices for chronic total occlusions (CTO) repair and treatment of mitral valve disease (MVD). We also design and manufacture mechanical circulatory support devices, including the bioresorbable percutaneous ventricular assist device (BiVAD(TM)) used in advanced heart failure. Edwards Lifesciences Corporation is based in Irvine, California.

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