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Enanta Pharmaceuticals Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary3 Dec, 2025
Key achievements and pipeline updates
Advanced RSV program with compelling phase II-B data in high-risk adults, showing symptom reduction and decreased hospitalization.
Expanded into immunology and inflammation, nominating EDP-978 as a clinical candidate for KIT inhibition, targeting mast cell-driven diseases.
STAT6 program aims for an oral Dupixent-like profile, with a candidate showing efficacy in animal models of atopic dermatitis and asthma.
IND filing for KIT inhibitor expected in Q1 2026; STAT6 IND planned for the second half of next year.
A third immunology target announcement is anticipated in the coming weeks.
RSV market and clinical development
RSV remains a significant unmet need, affecting millions annually, especially high-risk groups like pediatrics and older adults with comorbidities.
Phase II-B data showed about a week reduction in symptoms and fewer hospitalizations in high-risk adults.
Phase III trial likely to focus on symptom resolution and hospitalization, with an estimated 500–700 participants.
Discussions with the FDA regarding trial design are underway.
Immunology pipeline strategy and differentiation
Target selection focuses on unmet needs and areas where small molecules can offer advantages over monoclonal antibodies.
STAT6 candidate offers high selectivity and oral dosing, aiming to address gaps left by current therapies like Dupixent.
KIT inhibitor EDP-978 demonstrates subnanomolar potency, good selectivity, and favorable PK for daily oral dosing.
Selectivity is emphasized to minimize off-target effects, especially for kinase inhibitors.
Phase I trials for both programs will focus on safety, PK, and relevant biomarkers to establish differentiation.
RSV Phase 3 trial design and endpoints
STAT6: How overcome historical drugging challenges?
KIT inhibitor: Mitigate on-target tolerability?
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Next Enanta Pharmaceuticals earnings date
Q1 20269 Feb, 2026
Next Enanta Pharmaceuticals earnings date
Q1 20269 Feb, 2026
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Enanta Pharmaceuticals Inc is a biotechnology company focused on the research and development of small molecule drugs targeting viral infections and liver diseases. It specializes in therapies for hepatitis, respiratory infections, and other viral illnesses. The company is headquartered in Watertown, Massachusetts, and its shares are listed on the NASDAQ.
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