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Enlivex Therapeutics (ENLV) investor relations material

Enlivex Therapeutics Q3 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q3 2025 earnings summary14 Nov, 2025

Executive summary

  • Clinical-stage immunotherapy company focused on macrophage reprogramming, with Allocetra as lead candidate for osteoarthritis and sepsis indications.

  • Announced positive three-month topline data for Allocetra in moderate-to-severe knee osteoarthritis, showing significant efficacy and favorable safety profile.

  • Reprioritized pipeline to focus on inflammatory and autoimmune indications, reducing workforce and seeking external partnerships for oncology and sepsis programs.

Financial highlights

  • Net loss for nine months ended September 30, 2025 was $7.5M, down 23% from $9.8M in the prior year period; Q3 net loss was $2.2M, down 15% year-over-year.

  • Research and development expenses decreased 14% year-over-year to $6.2M for nine months, and 36% for Q3, reflecting lower clinical study and manufacturing costs.

  • General and administrative expenses rose 4% year-over-year to $3.0M for nine months, and 40% for Q3, mainly due to higher director fees and professional services.

  • Finance income, net, increased to $1.6M for nine months, driven by interest income and favorable currency fluctuations.

  • Cash and cash equivalents plus short-term deposits totaled $18.2M as of September 30, 2025.

Outlook and guidance

  • Existing cash resources expected to fund operations through end of 2026, including planned clinical milestones.

  • Anticipates continued operating losses and need for additional funding to advance clinical programs and potential commercialization.

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Frequently asked questions

Enlivex Therapeutics Ltd is an Israel-based clinical-stage biopharmaceutical company focused on developing allogeneic cell therapies for life-threatening immune-related diseases. The company’s lead investigational product is designed to modulate the immune system to restore immune balance in conditions such as sepsis, solid tumors, and other inflammatory disorders. Enlivex conducts clinical trials and research to advance its immunotherapy platform. The company is headquartered in Nes Ziona, Israel, and its shares are listed on the NASDAQ.

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