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Entrada Therapeutics
Entrada Therapeutics (TRDA) investor relations material
Entrada Therapeutics 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.44th Annual J.P. Morgan Healthcare Conference summary14 Jan, 2026
Strategic pipeline progress and expansion
Advancing four clinical-stage programs in Duchenne muscular dystrophy (DMD) with data readouts expected in Q2 and Q4 2026 for ENTR-601-44, and mid-2026 for ENTR-601-45.
Expansion into ocular diseases with the nomination of ENTR-801 for Usher syndrome type 2A and plans for a second candidate in 2026.
Partnership with Vertex on myotonic dystrophy type 1 (DM1) progressing, with global Phase 1/2 study enrollment and dosing to complete mid-2026.
Pipeline includes ongoing discovery in neuromuscular, ocular, and undisclosed disease areas.
Financial runway extends into Q3 2027, supporting continued R&D and expansion.
Clinical and scientific differentiation
EEV platform enables 25-fold improvement in endosomal escape, leading to higher muscle concentrations at lower doses compared to antibody-based therapies.
Optimized PMO sequences and satellite cell uptake are expected to drive functional benefit and safety.
Healthy volunteer studies showed zero treatment-related adverse events and strong target engagement.
Lower drug load reduces risk of antibody response and manufacturing burden.
Data from ENTR-601-44 expected to de-risk subsequent DMD programs due to shared EEV technology.
Regulatory and commercialization strategy
Ex-U.S. clinical strategy accelerates data collection and supports U.S. FDA accelerated approval pathway.
ELEVATE 44-201 study designed to support U.S. accelerated approval and global registration.
Targeting over 14,000 DMD patients in the U.S. and Europe with multiple exon-skipping therapies.
Ocular program aims for clinically relevant exon skipping and favorable dosing intervals.
Ongoing efforts to expand into metabolic, CNS, and other undisclosed indications.
Explain the low-dose advantage over antibody therapies
What early ENTR-801 data supports favorable dosing?
How is kidney liability mitigated for Entrada's oligos?
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Next Entrada Therapeutics earnings date
Guggenheim Securities Emerging Outlook: Biotech Summit 202611 Feb, 2026
Entrada Therapeutics
Next Entrada Therapeutics earnings date
Guggenheim Securities Emerging Outlook: Biotech Summit 202611 Feb, 2026
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Frequently asked questions
Entrada Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing a new class of medicines that target intracellular sites traditionally considered unreachable by conventional therapies. The company's proprietary Endosomal Escape Vehicle technology facilitates the efficient intracellular delivery of diverse therapeutic modalities, including RNA, antibodies, and enzymes. This approach is being applied to develop treatments for a range of diseases, particularly in neuromuscular, ocular, metabolic, and immunological areas. The company is headquartered in Boston, Massachusetts, and its shares are listed on the NASDAQ.
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