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Kyntra Bio
Kyntra Bio (KYNB) investor relations material
Kyntra Bio Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary10 Nov, 2025
Executive summary
Completed the sale of China operations to AstraZeneca for $220–$220.4 million, including $85 million enterprise value and $135–$135.4 million net cash, closing on August 29, 2025, and extending the cash runway into 2028.
Proceeds used to repay $75–$80.9 million senior term loan to Morgan Stanley Tactical Value, simplifying the capital structure.
Advanced FG-3246 (CD46-targeted ADC) and companion diagnostic FG-3180 in metastatic castration-resistant prostate cancer, initiating Phase 2 monotherapy trial in Q3 2025.
Progressed Roxadustat for anemia in lower-risk myelodysplastic syndromes (MDS), with positive FDA Type C meeting and Phase 3 protocol submission planned for Q4 2025.
Retained rights to Roxadustat in the U.S., Canada, Mexico, and other non-AstraZeneca/Astellas markets; Astellas continues commercialization in Europe and Japan.
Financial highlights
Q3 2025 total revenue from continuing operations was $1.1 million, up from $0.1 million in Q3 2024.
Net loss from continuing operations was $13.1 million ($3.25 per share), improved from $48.3 million ($12.01 per share) in Q3 2024.
Net income for Q3 2025 was $200.6 million, driven by $213.8 million income from discontinued operations (China divestiture), including a $52.2 million gain on divestiture.
Cash, cash equivalents, investments, and accounts receivable totaled $121.1 million as of September 30, 2025.
Full-year 2025 revenue guidance reiterated at $6–8 million; operating costs and expenses guidance updated to $50–60 million, a 70% reduction from 2024.
Outlook and guidance
Cash and equivalents expected to fund operations into 2028, not including costs for a self-funded Roxadustat Phase 3 trial; if self-funded, runway could extend into the second half of 2027.
Interim results from FG-3246 Phase 2 monotherapy trial expected in the second half of 2026; topline results from the combination study with enzalutamide anticipated in Q1 2026.
Roxadustat Phase 3 protocol submission planned for Q4 2025; decision on self-funding or partnering expected by Q2 2026.
Focus on advancing FG-3246 in mCRPC and progressing Roxadustat Phase 3 in lower-risk MDS; evaluating partnership opportunities.
Anticipates continued operating losses and need for additional funding for ongoing R&D and commercialization efforts.
Roxadustat LR-MDS partnership drivers?
FG-3180 impact on FG-3246 patient selection?
Post-China sale investment priorities?
Roxadustat Phase III funding strategy
FG-3246 IST data success criteria
FG-3246 Phase II design efficacy improvements
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FibroGen Inc. is a biopharmaceutical company focused on the discovery, development, and commercialization of therapies for serious unmet medical needs, particularly in areas like fibrosis, oncology, and anemia. The company’s lead products target conditions such as chronic kidney disease-related anemia and idiopathic pulmonary fibrosis. The company is headquartered in San Francisco, California, and its shares are listed on the NASDAQ.
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