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Foghorn Therapeutics (FHTX) investor relations material
Foghorn Therapeutics Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Advanced FHD-909 Phase 1 dose-escalation trial for SMARCA4-mutant cancers, focusing on NSCLC, with enrollment progressing as planned since October 2024.
Selective CBP and EP300 degrader programs are on track for IND-enabling studies in 2026, targeting ER+ breast cancer, multiple myeloma, and DLBCL.
Completed $50 million direct financing in January 2026, extending cash runway into the first half of 2028.
Strengthened executive team with the appointment of a new CFO in February 2026.
Financial highlights
Collaboration revenues rose to $30.9 million for 2025, up from $22.6 million in 2024, driven by the Lilly collaboration.
Research and development expenses decreased to $85.5 million in 2025 from $94.5 million in 2024, mainly due to lower FHD-286 and personnel costs.
General and administrative expenses fell to $27.6 million in 2025 from $28.4 million in 2024.
Net loss narrowed to $74.3 million in 2025 from $86.6 million in 2024.
Cash, cash equivalents, and marketable securities totaled $158.9 million as of December 31, 2025.
Outlook and guidance
Cash runway expected into the first half of 2028, supported by recent financing.
IND-enabling studies for CBP and EP300 degrader programs anticipated in 2026.
Advancing ARID1B degrader program toward in vivo proof of concept in 2026.
Potential combination studies for FHD-909 in NSCLC pending Phase 1 results.
- Pipeline leverages chromatin biology with strong Lilly partnership and promising oncology assets.FHTX
Investor presentation11 Mar 2026 - SMARCA2 clinical progress and pipeline advances position the company for key mid-year decisions.FHTX
TD Cowen 46th Annual Health Care Conference3 Mar 2026 - SMARCA2 and CBP/EP300 programs advance, with key clinical milestones expected this year.FHTX
Guggenheim Securities Emerging Outlook: Biotech Summit 202612 Feb 2026 - Selective chromatin regulator targeting advances, with promising clinical and pipeline progress.FHTX
Guggenheim Securities 2nd Annual Healthcare Innovation Conference3 Feb 2026 - Advancing chromatin-targeted oncology pipeline with key partnerships and strong financial runway.FHTX
Morgan Stanley 22nd Annual Global Healthcare Conference22 Jan 2026 - Advancing chromatin-targeted therapies with clinical and preclinical programs for major cancer indications.FHTX
Jefferies London Healthcare Conference 202413 Jan 2026 - Advancing chromatin-targeted therapies in AML and SMARCA4-mutant cancers, with new ARID1B focus.FHTX
7th Annual Evercore ISI HealthCONx Conference12 Jan 2026 - FHD909 demonstrates strong anti-tumor activity in SMARCA4-mutated NSCLC and pipeline progress.FHTX
AACR Annual Meeting 202524 Dec 2025 - Biotech seeks to raise $300M for gene expression-targeted therapies, emphasizing R&D and governance.FHTX
Registration Filing16 Dec 2025
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