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NextCure Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary3 Dec, 2025
Key program updates
SIM0505, targeting CDH6, is in phase I with data expected in the first half of next year; enrollment ongoing in both China and the US, leveraging prior safety data to accelerate progress.
LNCB74, targeting B7-H4, uses a stable beta-glucuronidase linker and is advancing to higher dose cohorts after strong safety results; data also anticipated in the first half of next year.
Both ADCs focus initially on ovarian and endometrial cancers, with potential for broader application based on target expression.
Combination or sequential use of ADCs is being explored, with future treatment paradigms likely to be driven by tumor expression profiling and resistance patterns.
Pipeline includes non-oncology assets in osteogenesis imperfecta and Alzheimer's, with plans to spin these out or partner, while maintaining focus and ownership in ADCs.
Financial and strategic outlook
Cash position is just under $50 million, sufficient to fund operations into the first half of 2027 and cover key data milestones for both lead ADC programs.
Additional financing is planned for early next year to support advancement into phase II trials.
Business development efforts are ongoing for non-core assets, with a strategy shift toward spinning out non-oncology programs and retaining ADC ownership.
SIM0505 payload: What safety advantages?
LigaChem linker: How does it enable higher LNCB74 doses?
How will ADC sequencing impact future treatment paradigms?
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Q4 202512 Mar, 2026
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Frequently asked questions
NextCure Inc. is a clinical-stage biopharmaceutical company focused on the discovery and development of novel immunomedicines to address cancer and other immune-related diseases by restoring normal immune function. The company's pipeline includes NC410, designed to block immune suppression mediated by LAIR-1; NC762, a monoclonal antibody targeting B7-H4, a protein found on various tumor types; and NC525, which targets LAIR-1 to eliminate AML blast cells and leukemic stem cells while sparing normal blood cells. NextCure's research also extends to preclinical evaluations of additional immunomodulatory molecules. NextCure is headquartered in Beltsville, Maryland, and its shares are listed on the Nasdaq.
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