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PolyPid
PolyPid (PYPD) investor relations material
PolyPid 2nd Annual Lytham Partners Healthcare Investor Summit summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.2nd Annual Lytham Partners Healthcare Investor Summit summary15 Jan, 2026
Platform technology and pipeline
Developing a unique platform for prolonged, linear local drug delivery, combining polymers and lipids in a self-assembling matrix.
Over 170 patents protect the technology, with headquarters in New Jersey and Israel.
Lead asset D-PLEX 100 is in late-stage development, with NDA submission planned for early this year.
Pipeline includes a GLP-1 program, with preclinical and efficacy data expected later this year.
Clinical results and regulatory progress
D-PLEX 100 targets the large U.S. surgical site infection market, covering 12 million procedures annually.
Phase 3 trial in colorectal resection showed a 40% reduction in infection, mortality, and re-intervention rates (from 18% to 9.9%).
Statistically significant results across all primary and secondary endpoints, including a drop in infection rate from 10% to 3.8%.
Achieved 60% reduction in severe sepsis scores and maintained robust results in minimally invasive procedures.
Pre-NDA meeting with FDA resulted in alignment on approval and submission process; NDA submission imminent.
Commercialization and market strategy
Product has breakthrough therapy, fast track, and QIDP designations, making it eligible for priority review and a six-month FDA review period.
Commercial launch planned with a U.S. partner; discussions are ongoing and announcement expected around NDA submission.
Hospitals bear direct costs of surgical site infections and face CMS penalties, making cost-saving solutions attractive.
Eligible for NTAP program, providing additional hospital reimbursement in the first 2-3 years post-launch.
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Next PolyPid earnings date
Q4 202511 Feb, 2026
PolyPid
Next PolyPid earnings date
Q4 202511 Feb, 2026
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Frequently asked questions
PolyPid Ltd. is a late-stage biopharmaceutical company focused on enhancing surgical outcomes through innovative drug delivery systems. The company's proprietary PLEX (Polymer-Lipid Encapsulation Matrix) technology is designed to enable localized, prolonged, and controlled release of active pharmaceutical ingredients at the surgical site. This technology aims to optimize therapeutic efficacy and minimize side effects by maintaining a consistent drug presence over an extended period. The company is headquartered in Petach Tikva, Israel, and its shares are listed on the NASDAQ.
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