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Pulse Biosciences (PLSE) investor relations material
Pulse Biosciences Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Technology overview and differentiation
Nanosecond PFA delivers ultra-short, high-amplitude pulses with less overall energy, enabling disruptive therapies for large unmet clinical needs.
The platform is protected by 215 issued patents (up 35 in the past year) and 100 pending, providing a strong proprietary moat.
Mechanism of action is non-thermal, causing regulated cell death without damaging nerves or blood vessels, and allows for repeated ablation without temperature rise.
Enables procedures without general anesthesia, moving treatments closer to outpatient settings and increasing system flexibility.
Supported by over 1,000 publications, with dozens specific to the company, and seven FDA clearances including a breakthrough device designation.
Market strategy and financials
Targeting three main markets: thyroid, cardiac surgery, and electrophysiology (EP), with a current combined value of $6 billion, expected to grow to $16 billion in the next few years.
Employs a hybrid business model: direct commercialization for low-resistance markets (e.g., thyroid) and partnerships for capital-intensive markets (e.g., EP).
Strong balance sheet with $95 million in cash at Q3 end and a projected $36 million burn for 2024, increasing with two IDEs and a commercial launch in 2025.
Revenue generation has begun and is expected to grow, with strong inside ownership.
Board led by experienced industry figures and supported by key opinion leaders and clinical experts.
Clinical progress and commercialization
Thyroid: Launched limited market release for minimally invasive, thyroid-sparing ablation, targeting 250,000 new benign cases annually; strong early uptake and ongoing post-market studies.
Cardiac surgery: IDE underway for AFib ablation during open heart surgery, with published European feasibility data and rapid lesion creation (2.5 seconds per lesion).
EP: Filed for IDE, expecting first patient enrollment soon; ablation times as low as five seconds, total procedure times five to ten minutes, and compatibility with multiple mapping systems.
Commercialization initiated in thyroid, with plans to expand as clinical and regulatory milestones are achieved.
Pipeline includes additional therapy targets beyond current focus areas.
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