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Seres Therapeutics (MCRB) investor relations material
Seres Therapeutics Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Prioritized development of live biotherapeutic programs for inflammatory and immune diseases, focusing on SER-603 for inflammatory bowel disease and SER-155 for immune checkpoint inhibitor-related enterocolitis.
Completed enrollment in the SER-155 investigator-sponsored trial for irEC, with data expected in Q2 2026.
Leadership changes include the appointment of Richard N. Kender as Executive Chair and interim CEO.
Financial highlights
Net income from continuing operations was $5.7 million for 2025, compared to a net loss of $125.8 million in 2024, driven by lower operating expenses and gains from the VOWST sale.
Fourth quarter 2025 net loss from continuing operations was $15.3 million, similar to $15.7 million in Q4 2024.
R&D expenses for 2025 were $49.1 million, down from $64.6 million in 2024; Q4 2025 R&D expenses were $11.7 million, down from $12.8 million in Q4 2024.
G&A expenses for 2025 were $39.2 million, down from $53.2 million in 2024; Q4 2025 G&A expenses were $7.5 million, down from $12.5 million in Q4 2024.
Manufacturing services expenses rose to $6.5 million in 2025 from $3.5 million in 2024, with reimbursement recognized in other income.
Outlook and guidance
Cash and cash equivalents totaled $45.8 million as of December 31, 2025, expected to fund operations through Q3 2026.
Actively seeking partnerships and additional funding to support pipeline advancement, especially for SER-155 Phase 2.
- Leadership changes and SER-155 data in Q2 2026 highlight strategic and clinical progress.MCRB
Status update3 Mar 2026 - VOWST sale to Nestlé secures $155M upfront, funds pipeline, and extends cash runway into late 2025.MCRB
Investor Update2 Feb 2026 - VOWST sale to Nestlé boosts cash, retires debt, and shifts focus to biotherapeutic pipeline.MCRB
Q2 20241 Feb 2026 - Significant reduction in bloodstream infections and antibiotic use with strong safety profile.MCRB
Study Result20 Jan 2026 - SER-155 reduced infections in allo-HSCT patients, driving pipeline focus and FDA engagement.MCRB
2024 Cantor Fitzgerald Global Healthcare Conference20 Jan 2026 - SER-155 cut BSIs by 77% in allo-HSCT patients; VOWST sale funded debt retirement and growth.MCRB
Q3 202414 Jan 2026 - SER-155 achieved a 77% reduction in bloodstream infections, driving pivotal trial preparations.MCRB
Piper Sandler 36th Annual Healthcare Conference12 Jan 2026 - SER-155 delivers 77% infection risk reduction, with VOWST sale funding pipeline expansion.MCRB
43rd Annual J.P. Morgan Healthcare Conference 202510 Jan 2026 - SER-155 cut BSI risk by 77% in allo-HSCT; VOWST sale extends cash runway into 2026.MCRB
Q4 202426 Dec 2025
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