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Extra Everything: The Story of Chipotle
Chipotle's story from a single restaurant to a nationwide chain, through crisis and turnaround, built on one of the strongest models in the industry.
Shattuck Labs
Shattuck Labs (STTK) investor relations material
Shattuck Labs Corporate presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Corporate presentation summary7 May, 2026
Strategic focus and mission
Dedicated to developing novel biologics for inflammatory and immune-mediated diseases, emphasizing scientific excellence and resource stewardship.
Aims to create innovative therapeutics by challenging conventional approaches and focusing on patient impact.
Pipeline and lead program
Lead asset SL-325 is a potentially first-in-class DR3 blocking antibody targeting the TL1A/DR3 axis for inflammatory bowel disease (IBD), with Phase 1 enrollment complete and data expected in Q2 2026.
Pipeline includes SL-425 (extended half-life DR3 antibody) and bispecific antibodies targeting DR3 and other validated IBD targets.
Blocking DR3 may offer more potent and durable inhibition of the TL1A/DR3 axis and lower immunogenicity compared to TL1A blockade.
Scientific rationale and differentiation
DR3 is constitutively and more abundantly expressed in GI tissue and blood of IBD patients than TL1A, supporting its selection as a therapeutic target.
Preclinical data show DR3 inhibition fully prevents CD-like ileitis in mouse models, outperforming TL1A inhibition.
SL-325 demonstrates picomolar binding affinity to DR3, does not bind decoy receptor DcR3, and blocks both monomeric and trimeric TL1A.
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Latest events from Shattuck Labs
- SL-325 Phase 1 enrollment completed; net loss rose to $14.8M, cash runway into 2029.STTK
Q1 20267 May 2026 - Virtual annual meeting to vote on directors, auditor, compensation, and equity plan amendment.STTKProxy filing8 Apr 2026
- Shareholders will vote on director elections, auditor ratification, executive pay, and equity plan changes.STTKProxy filing8 Apr 2026
- SL-325 offers a novel, potent approach to IBD by targeting DR3, with Phase 2 trials planned.STTKCorporate presentation5 Mar 2026
- SL-325 clinical progress and a strengthened cash position extend operational runway into 2029.STTKQ4 20255 Mar 2026
- DR3 antibody program targets superior efficacy and lower immunogenicity in IBD, with phase IIb trial soon.STTKTD Cowen 46th Annual Health Care Conference2 Mar 2026
- SL325, a DR3-targeting antibody, advances to clinical trials for IBD with IND planned mid-2025.STTKPiper Sandler 36th Annual Healthcare Conference3 Feb 2026
- SL-172154 plus azacitidine achieved high response rates and manageable safety in HR-MDS and TP53 mutant AML.STTKStudy Update3 Feb 2026
- SL-172154 discontinued for marginal benefit; SL-325 DR3 antibody advances to phase I in 2026.STTKStudy Update20 Jan 2026
Next Shattuck Labs earnings date
Q2 202631 Jul, 2026
Shattuck Labs
Next Shattuck Labs earnings date
Q2 202631 Jul, 2026
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Amina0781App Store
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@theshortbearx.com
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