Shoulder Innovations (SI) investor relations material

Market opportunity and industry trends

• Global annual shoulder arthroplasty market estimated at $2.8B, with strong growth expected, especially in outpatient and ASC settings.

• Shoulder pain is highly prevalent, affecting 1 in 5 people over 65 in the U.S., yet surgical treatments remain underutilized.

• Shoulder arthroplasty is one of the fastest-growing MedTech segments, with U.S. procedures projected to reach ~250,000 in 2025.

• Market is shifting toward reverse arthroplasty and inlay designs, now comprising over 70% of procedures.

Product innovation and clinical differentiation

• InSet Glenoid implant addresses glenoid loosening, a major complication in shoulder arthroplasty, with data showing 100% implant survivorship and 87% reduction in "rocking horse" motion.

• InSet technology supports both anatomic and reverse procedures, enabling seamless revision and conversion surgeries.

• ProVoyance 3D platform uses AI/ML for patient-specific surgical planning, improving implant positioning and outcomes.

• Instrument system reduces surgical tray usage from up to 9 to just 2, lowering costs and complexity, especially for ASCs.

Financial performance and growth drivers

• Revenue reached $47.3M in 2025, with a 57% CAGR from 2023 to 2025 and gross margins of 76.5%.

• 1,976 implant systems sold in the latest period, up 62% year-over-year, with rapid surgeon adoption.

• $124M in cash and equivalents as of the latest quarter.

• Growth driven by new indications, higher ASPs, international expansion, and increased penetration among high-volume surgeons.