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Sutro Biopharma
Sutro Biopharma (STRO) investor relations material
Sutro Biopharma 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.44th Annual J.P. Morgan Healthcare Conference summary15 Jan, 2026
Strategic transformation and leadership
Undertook a strategic pivot in 2024, redefining strategy, right-sizing the team, and accelerating the pipeline.
New leadership team with deep ADC experience and a focus on execution and discipline.
Reduced team and expenses by two-thirds, extending cash runway to at least mid-2027, not including potential collaboration milestones.
Emphasis on partnerships to advance programs and manage resources efficiently.
ADC pipeline and technology differentiation
Advancing a differentiated pipeline of single- and dual-payload ADCs, with three INDs planned over the next three years.
STRO-004, STRO-006, and STRO-227 are lead candidates, with initial clinical data and IND submissions expected between mid-2026 and 2027.
STRO-004 (Tissue Factor ADC) is in phase I, showing robust preclinical activity and a high safety window (HNSTD 50 mg/kg), with Phase 1 data expected mid-2026.
STRO-006 (integrin beta-6 ADC) targets lung cancer, with IND on track for 2026 and strong preclinical results.
STRO-227 (PTK7 dual-payload ADC) aims to overcome resistance, with IND submission anticipated in 2026-2027.
Platform innovation and safety profile
Proprietary platform enables high-throughput antibody screening, optimized linkers, and payload combinations to maximize efficacy and minimize toxicity.
Use of non-natural amino acids and click chemistry stabilizes linker-payload, reducing free payload and improving safety.
Fc-silent antibodies reduce risks like ILD and pneumonitis, enhancing safety especially in lung cancer applications.
Cell-free platform supports innovation in dual-payload ADCs, enabling tailored drug ratios and broad payload diversity.
Dual payload ADCs deliver combination therapies in a targeted way, overcoming resistance and expanding therapeutic windows.
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Next Sutro Biopharma earnings date
Q4 202527 Mar, 2026
Sutro Biopharma
Next Sutro Biopharma earnings date
Q4 202527 Mar, 2026
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Frequently asked questions
Sutro Biopharma Inc. is a biotechnology company specializing in the discovery, development, and manufacturing of therapeutics aimed at treating cancer. The company leverages its proprietary cell-free protein synthesis platform, XpressCF, to design and produce novel, targeted antibody-drug conjugates (ADCs), bispecific antibodies, and other protein therapeutics. Sutro's focus is on creating therapies that precisely target and eliminate cancer cells while minimizing damage to healthy tissues, advancing treatment options for patients with difficult-to-treat cancers. The company is headquartered in San Francisco, California, and its shares are listed on the NASDAQ.
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