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Theravance Biopharma KOL Event summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.KOL Event summary8 Dec, 2025
Introduction and agenda
Event focused on ampreloxetine for neurogenic orthostatic hypotension (NOH/nOH) in multiple system atrophy (MSA), covering unmet need, clinical evidence, study design, commercial opportunity, and strategic plans.
Agenda included company overview, CEO remarks, KOL-led disease and trial overview, clinical development update, commercial strategy, and Q&A.
KOL background and credentials
Dr. Horacio Kaufmann, professor at NYU and director of the Dysautonomia Center, F.B. Axelrod Professor of Neurology, has over 40 years of experience treating severe orthostatic hypotension and presented on nOH in MSA and clinical trial data.
Market insights and analysis
NOH/nOH in MSA is a rare, disabling condition affecting ~40,000 US patients, with high unmet need and limited durable therapies.
Only about a third of MSA patients receive therapy; current treatments are short-acting, require frequent dosing, and are not validated for MSA, with 70% remaining symptomatic.
Care is concentrated among a few hundred specialists and centers of excellence, enabling a lean commercial model and efficient targeting.
Rare disease pricing and orphan drug status position ampreloxetine for premium value and blockbuster potential.
Significant opportunities exist in Europe and Asia, with ~150,000 patients in China and Japan and 45-60K in Europe.
What drives physician readiness for ampreloxetine?
How does the commercial model achieve efficiency?
Ampreloxetine's broader impact on patient well-being?
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Next Theravance Biopharma earnings date
Q4 202523 Feb, 2026
Next Theravance Biopharma earnings date
Q4 202523 Feb, 2026
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Frequently asked questions
Theravance Biopharma Inc. is a biopharmaceutical company that focuses on the discovery, development, and commercialization of respiratory and organ-selective medicines. The company's primary product is YUPELRI (revefenacin), a once-daily nebulized therapy used for the maintenance treatment of chronic obstructive pulmonary disease (COPD). Theravance Biopharma is also involved in the development of Ampreloxetine, an investigational norepinephrine reuptake inhibitor, targeting neurogenic orthostatic hypotension, and has collaborations for additional research in respiratory and immunological disorders. The company is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.
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