Vera Therapeutics
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Vera Therapeutics (VERA) investor relations material

Vera Therapeutics Corporate presentation summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Corporate presentation summary28 Jan, 2026

Company overview and financials

  • Founded in 2016 in San Francisco, led by an experienced management team with backgrounds at major biotech firms.

  • Raised over $1.8B since IPO in 2021, with $779M in cash and equivalents as of December 2025 and access to an additional $425M in non-dilutive capital.

  • Holds exclusive global rights to develop and commercialize atacicept, VT-109, and MAU868.

Atacicept mechanism and clinical profile

  • Atacicept is a dual BAFF/APRIL inhibitor, designed as a native human TACI-Fc fusion protein for precision B cell and autoantibody modulation.

  • Demonstrates robust efficacy in IgA nephropathy (IgAN), with significant reductions in proteinuria, Gd-IgA1, and hematuria, and stabilization of eGFR.

  • Offers at-home, once-weekly administration with high patient retention and a safety profile comparable to placebo, with no serious or opportunistic infections.

Clinical trial results and design

  • Phase 3 ORIGIN 3 trial fully enrolled, randomized, placebo-controlled, with primary endpoint of UPCR reduction at 36 weeks and secondary endpoint of eGFR at 104 weeks.

  • Interim analysis showed a 46% reduction in UPCR for atacicept vs. 7% for placebo at 36 weeks, with consistent efficacy across subgroups.

  • Gd-IgA1 reduction of 68% and 81% hematuria resolution observed; adverse events were generally mild or moderate and balanced between groups.

How to leverage 'most desired' IgAN agent status
Impact of delayed eGFR data on full approval
Prioritize atacicept's autoimmune pipeline expansion
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Q4 202524 Mar, 2026
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Q4 202524 Mar, 2026

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Frequently asked questions

Vera Therapeutics, Inc. is a clinical-stage biotechnology company engaged in developing and commercializing treatments aimed at serious immunological diseases. Their portfolio includes atacicept, a fusion protein undergoing clinical trials for immunoglobulin A nephropathy and Phase II trials for lupus nephritis. Another significant development in their pipeline is MAU868, a monoclonal antibody targeting the BK virus in transplant patients. The company is headquartered in Brisbane, California, and its shares are listed on the NASDAQ.

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