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Whitehawk Therapeutics (WHWK) investor relations material
Whitehawk Therapeutics Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary3 Dec, 2025
Company overview and platform strategy
Formed by in-licensing a three-asset ADC portfolio, completed earlier this year, with clinical programs starting this quarter.
ADC platform features high-stability chemistry to limit free payload release, aiming for better potency and fewer side effects.
Platform developed by Hangzhou DAC, with related assets in dose escalation studies in China; data expected in 2026.
Target selection focuses on validated but not overcrowded markers to maximize first or second-to-market opportunities.
Cash runway extends through early 2028, supported by $163 million in financing and asset sales.
Lead program HWK-007 (PTK7 ADC)
PTK7 is broadly expressed in 70% of tumors and minimally on normal tissue, making it an ideal ADC target.
IND submission planned this year; preclinical data to be presented in the first half of 2026.
Program leverages a high-affinity, attenuated antibody and improved bioconjugation for stability and reduced side effects.
Initial clinical focus on lung, ovarian, and endometrial cancers, with potential for broader indications.
Competitive field with multiple companies launching PTK7 programs; 2026 expected to be pivotal for this target.
HWK-016 (MUC16 ADC)
Targets MUC16, highly expressed in gynecological cancers, with a unique approach to avoid circulating CA125 and improve tumor targeting.
IND submission in Q4, clinical trial start in Q1, and preclinical data expected in the first half of 2026.
Initial indications are ovarian and endometrial cancers, with potential expansion to pancreatic, mesothelioma, and some lung cancers.
Prior MUC16 programs showed efficacy but were limited by targeting issues; current approach aims to overcome these.
Market opportunity significant due to unmet need in second and third-line settings.
How will platform stability translate to clinical edge?
With 2026 as "year of PTK7," how will HAWK-007 achieve best-in-class?
What is the strategy for MUC16 in less crowded areas?
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Next Whitehawk Therapeutics earnings date
Q4 202513 Mar, 2026
Next Whitehawk Therapeutics earnings date
Q4 202513 Mar, 2026
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