Novartis (NOVN) Status Update summary

Strategic focus and business transformation

• Evolved from a diversified healthcare conglomerate to a pure-play innovative medicines company, focusing on four core therapeutic areas and scaling data science and technology for operational excellence.

• Social impact and sustainability efforts are structured around global health innovation, inclusion and access, environmental sustainability, ethics, and people experience.

Global health innovation and pipeline

• Maintains a robust Global Health pipeline, with 11 clinical trials across 14 low and middle-income countries, targeting neglected diseases like malaria, sickle cell, leishmaniasis, dengue, and Chagas disease.

• Developed new antimalarial therapies, including ganaplacide/lumefantrine and KLU156, both showing high efficacy and potential to address drug resistance.

• Launched Coartem Baby, the first antimalarial for newborns and infants under 5 kg, addressing a critical treatment gap.

• Ongoing commitment to neglected tropical diseases, with significant R&D investment and partnerships to address unmet needs in low- and middle-income countries.

• Partnerships with organizations like Medicines for Malaria Venture drive innovation and access in malaria treatment.

Inclusion, access, and health equity

• Introduced Inclusive Health Accelerators (IHAs) to address disparities in access to innovative medicines, starting in the U.S. with a focus on prostate cancer, cardiovascular disease, and breast cancer.

• IHAs use data-driven approaches to identify underserved populations and implement targeted interventions, such as community education, patient navigation, provider training, and impact measurement.

• Access Principles are embedded across the product lifecycle, focusing on affordability, health systems strengthening, and adaptive development.

• Plans to expand IHAs to other markets, embedding access principles into country operations for sustainable business growth.

• IHAs are launching in the US in 2026, with expansion to other geographies planned.