Prime Medicine (PRME) Proxy filing summary

Voting matters and shareholder proposals

• Election of Michael Kelly and David Schenkein, M.D. as Class I Directors is up for shareholder vote at the 2026 Annual Meeting.

• Ratification of PricewaterhouseCoopers LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2026, is proposed.

• Additional business may be addressed if properly brought before the meeting or any adjournments.

Board of directors and corporate governance

• Michael Kelly and David Schenkein, M.D. are nominated for election as Class I Directors.

Audit committee and external auditor matters

• Proposal to ratify PricewaterhouseCoopers LLP as the independent auditor for the 2026 fiscal year.