Sera Prognostics (SERA) H.C. Wainwright 26th Annual Global Investment Conference 2024 summary

Key challenges in pregnancy care

• Preterm birth affects 1 in 10 pregnancies in the US, with significant disparities among populations and a $25 billion annual cost burden.

• Black women experience double the rate of preterm birth compared to Caucasian women.

• Most preterm births occur without warning, making early detection critical.

Innovation and clinical solution

• Developed a proteomics-based PreTRM test to identify risk of spontaneous preterm birth in healthy, asymptomatic singleton pregnancies.

• Test is administered between weeks 18-21, aligning with routine second trimester care.

• Intervention bundle includes low-dose aspirin, vaginal progesterone, and structured nurse calls.

Clinical and economic impact

• AVERT study showed a week-long reduction in neonatal hospital stay and 18% reduction in severe complications.

• For the earliest preterm births, NICU stays were reduced by nearly a month, with significant cost savings.

• PRIME pivotal trial was halted early for success, confirming health and economic benefits.

• Elevance modeling showed $1,600 in cost savings per member tested, with results realized within six months.